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The Science Behind Lume

The Gut-Brain Axis
Microbiome Imbalance
Vital Micronutrients
Brain Inflammation
It all starts in…the gut?

That’s right. Many of the 39 trillion bacteria in your gut help break down nutrients into key compounds, like neurotransmitters and fatty acids, that support your brain function.

In fact, 95% of your body’s serotonin is produced in your gut.
Your gut and brainare in constant communication through a complex network of nerves, chemical signals, and gut bacteria—knownas the gut-brain axis.
Insufficient beneficial bacteria and excess inflammatory bacteria can disrupt the delicate systems of the gut-brain axis that regulate our mood.

This results in depressive symptoms, heightened anxiety, and even disrupted sleep patterns.

Disruptions in this system can contribute to low mood and chronic stress, driven by 3 key dysregulations:

  1. microbiome
  2. micronutrition
  3. neuroinflammation
While micronutrients are essential for healthy cellular function, many people’s diets lack the complete spectrum of daily micronutrients.

These deficiencies put individuals at an increased risk of depression and anxiety.
Brain inflammation, caused by harmful bacteria, activates the body's inflammatory pathways. This process is linked to cognitive decline and mood disorders.
3

Reduce neuro-inflammation linked to poor mental health outcomes

Reduce neuro-
inflammation
‍linked to poor
mental health
outcomes

Eicosapentaenoic acid (EPA) reduces neuro-inflammation, helping to alleviate the severity of mood disorders (Nature).

Lume delivers EPA in a form that is 5x more bioavailable or absorbable than typical supplements. This means more effective improvements in your mental health.

Eicosapentaenoic acid (EPA)

  • Eicosapentaenoic acid is an Omega-3 poly unsaturated fatty acid.
  • Ingredient Form:
    fish-based, Omega-3
    Source: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍JAMA, Nature

Vitamin D3

Nutrient deficiencies are more prevalent and significant than we might expect.

For instance, 35% of Americans lack Vitamin D which is linked to a 75% higher risk of depression.

Iron

Nutrient deficiencies are more prevalent and significant than we might expect.

For instance, 35% of Americans lack Vitamin D which is linked to a 75% higher risk of depression.

Eicosapentaenoicacid
(EPA)
1

Promote a healthy microbiome for signaling and digestion

Promote a
healthy
microbiome
‍for signaling
and digestion

Lume includes 14 probiotic strains clincally proven to reduce depressive symptoms.These strains were derived from Nature and JAMA clinical studies. Our strain choice will evolve with the latest research.

Eicosapentaenoic acid (EPA)

  • 14 targeted probiotic strains from Nature and JAMA clinical studies.
  • Ingredient Form: lact., bifido., and strepto bacterial families.Source: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍JAMA, Nature

Vitamin D3

Nutrient deficiencies are more prevalent and significant than we might expect.

For instance, 35% of Americans lack Vitamin D which is linked to a 75% higher risk of depression.

Iron

Nutrient deficiencies are more prevalent and significant than we might expect.

For instance, 35% of Americans lack Vitamin D which is linked to a 75% higher risk of depression.

Streptococcus
thermophilis
Bifidobacterium breve
Bifidobacterium
longum
Bifidobacterium
infantis
Lactobacillus
acidophilus
Bifidobacterium
bifidum
Lactobacillus
helveticus
Lactobacillus
plantarum
Bacillus subtilis
Lactobacillus paracasei
Lactobacillus casei
Lactococcus lactis
Lactobacillus delbrueckii
Lactobacillus rhamnosus
1

Address nutrient gaps linked to low mood & high stress

Address
nutrient gaps
‍linked to
low mood &
high stress

We did a literature review across all vitamins and minerals, and included the ones at the clinical dosage that were associated with an increased risk for mental illness or where supplementation improved symptoms.

L-Methylfolate Calcium

  • This specialized vitamin is used as a cofactor in neurotransmitter synthesis
  • Ingredient Form: L-Methylfolate CalciumSource: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍JAMA, Nature

Zinc

  • Critical for brain cell growth and immune response.
  • Ingredient Form: zinc gluconateSource: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍JAMA, Nature

Vitamin D3

  • Vitamin D, the sunny vitamin, deficiency is linked to depression and anxiety risk.
  • Ingredient Form: cholecalciferol Source: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍ScienceDirect, BMC Psychiatry

Iron

  • Iron deficiency affects 25% of the general population, which is linked to higher risk of mood disorders.
  • Ingredient Form: Iron bisglycinateSource: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍Current Psychiatry, BMC Psychiatry

Vitamin B12

  • Promotes healthy nerve function and regulates neurotransmitters.
  • Ingredient Form: methylcobalminSource: Saskatoon, Canada Supplier: Aker
  • Research studies:Pubmed, Neuropsych Dis Tr, Open Nuero. J

Niacin

  • Niacin helps convert food into energy and supports neurotransmitter function.
  • Ingredient Form: niacinamideSource: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍BMC Psychiatry

Niacin

  • Niacin helps convert food into energy and supports neurotransmitter function.
  • Ingredient Form: niacinamideSource: Saskatoon, Canada Supplier: Aker
  • Research studies:
    ‍BMC Psychiatry

Vitamin D3

Nutrient deficiencies are more prevalent and significant than we might expect.

For instance, 35% of Americans lack Vitamin D which is linked to a 75% higher risk of depression.

Iron

Nutrient deficiencies are more prevalent and significant than we might expect.

For instance, 35% of Americans lack Vitamin D which is linked to a 75% higher risk of depression.

L-methylfolate
Calcium
Zinc
Vitamin D3
Iron
Vitamin B12
Niacin

Simple, stringent standards

Top Quality
Ingredients

  • clinically-proven
  • science-backed dosage
  • third-party verified for purity
  • traceably sourced

Responsible
Impact

  • 100% recyclable packaging
  • low-waste refill program
  • investment in mental health programs

Accessibility
First

  • halal
  • pescetarian (vegan coming soon...)
  • gluten-free
  • peanut-free

Created in collaboration with physicians and researchers

60+

scientific studies
across top journals:
Nature, JAMA, Frontiers

20

years of research
conducted over the past
two decades

1000+

participants
across all research
studies

30

clinical trials
demonstrating the power of our ingredients